Fig. 6. Proposed mechanism by which Hsp70 mediates the negative regulation of EMT within Losartan effect in PTCs from SHR. Left panel: schematic illustration showing four key events during tubular epithelial cells to myofibroblast transition. Right panel: Throughout the activation of the MAPKs cascade and the RhoA/ROCK pathway, AII regulates EMT markers. The Hps70 chaperone inhibits the signaling pathways that lead to EMT after Losartan AT₁ receptor blockage.